Flybe is cancelling its Liverpool to Amsterdam service with the last flight operating on March 29.
The regional carrier has decided to axe the three-times weekly route citing poor load factors and “failure to perform to expectations”.
The route has only been in operation since last September with the airline and airport hailing it as a “significant announcement” which should be “welcomed by the region’s business travellers”.
A Flybe spokesperson said: “Flybe carefully reviews the viability of all our routes on a regular basis.
“This is done not only to monitor where we can offer increased regularity on a given route but also where passenger numbers make a flight economically as well as environmentally harder to justify.
“With many opportunities to improve regional connectivity within the UK Flybe continues to refine its network to best serve our customers.
“Regretfully, the Amsterdam service has failed to perform to expectations and passenger numbers remain insufficient to justify its continued operation.”
Flybe said all passengers who have booked flights online for the upcoming summer season will be contacted in date priority order and offered a full refund or the option to be re-accommodated on an alternate flight.