Delta will operate exclusively at Heathrow Terminal 3 from September 14, and co-locate with joint venture partner Virgin Atlantic.
Delta will transfer its Atlanta, Minneapolis, Salt Lake City and Philadelphia flights from Terminal 4 to join its services to New York-JFK, Boston and Seattle that already operate from Terminal 3.
The airlines said the change will make it easier for travellers to manage their plans including any last-minute flight changes.
“Our joint venture with Virgin Atlantic is all about making it easy for our customers to connect between our airlines and having our Heathrow service under one roof is crucial to delivering a synched-up, more convenient service,” said Nat Pieper, Delta’s senior vice president Europe, Middle East and Africa.
“This enhances the travel experience for customers flying from Heathrow, one of the world’s most important international gateways, and marks a major milestone in our joint venture.”
Delta will operate 11 daily flights to eight US cities from Terminal 3. The two airlines’ summer schedule includes up to 40 daily nonstop flights between North America and the UK, of which, 28 operate between London Heathrow and the US.
Erik Varwijk, executive VP, commercial, Virgin Atlantic, said: "We are looking forward to our joint venture partner, Delta, joining us in Terminal 3 at London Heathrow.
“Once the switch goes ahead, our customers can enjoy an even more seamless experience flying from or through London. Whether they're flying Virgin Atlantic or Delta, they'll benefit from world-class service from the most punctual trans-Atlantic operators at Heathrow, and one of the world's best airport experiences."